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KMID : 0357920070410030193
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Korean Journal of Pathology
2007 Volume.41 No. 3 p.193 ~ p.197
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Sclerosing Mucoepidermoid Carcinoma of the Parotid Gland - A Case Report -
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Kim Hyun-Chul
Lee Ju-Han
Lee Eung-Seok
Kwon Soon-Young
Kim Taik-Kun
Kim Young-Sik
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Abstract
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Sclerosing mucoepidermoid carcinoma (SMEC) is a very rare tumor of the salivary gland. There have been eight cases of SMEC reported in the medical literature; this is the first reported case in Korea. A 51-year-old woman presented with a right infra-auricular mass that she had for 3 years. We performed superficial parotidectomy. Grossly, the resected parotid gland showed a well-circumscribed firm mass. Histologically, the tumor consisted of central solid or ductal tumor nests within a dense fibrous stroma surrounded by peripheral lymphoid infiltration. The tumor nests were composed of squamous, intermediate and mucin-secreting cells. However, the tumor cells lacked mitosis and nuclear anaplasia. The lymphoid cells were mostly composed of lymphocytes and plasma cells with occasional eosinophils and neutrophils. Im- munohistochemically, the tumor cells were positive for high- and low- molecular weight cytokeratins, cytokeratin 7, p16INK4A, Bcl-2 and cyclin D1. The patient also underwent radiation therapy. We report here on a case of SMEC of the parotid gland along with the immunohistochemical characteristics, and we review the relevant literature.
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KEYWORD
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Mucoepidermoid carcinoma, Sclerosis, Parotid gland
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